ABSTRACT
OBJECTIVE: Lymphocytes are the most important cells in defending the human body against viral pathogens. In this study, we aimed at investigating the relationship between lymphocyte blood levels and patient survival in COVID-19 patients hospitalized in the intensive care unit. PATIENTS AND METHODS: We retrospectively evaluated patients hospitalized with COVID-19 pneumonia in the intensive care unit. Patients were divided into two groups in terms of blood lymphocyte levels; increased lymphocyte and decreased lymphocyte groups on the 5th day of hospitalization. Mortality rates were compared between groups. RESULTS: Two groups were similar in terms of laboratory tests and comorbidities. Overall survival was 63.8% (n=102) in patients with increased lymphocytes and 33.2% (n=68) in patients with decreased lymphocytes. Mortality rates were significantly higher in decreased lymphocyte group than in increased lymphocyte group (p=0.003). CONCLUSIONS: Our study reveals that mortality is higher in patients with a lower lymphocyte count on the 5th day compared to the day of hospitalization.
Subject(s)
COVID-19 , Humans , Retrospective Studies , Follow-Up Studies , Intensive Care Units , LymphocytesABSTRACT
BACKGROUND: This study aimed to investigate pregnancy frequency and evaluate the factors affecting live births in hemodialysis (HD) patients. METHODS: Female HD patients whose pregnancy was retrospectively reported between January 1, 2014, and December 31, 2019. The duration of HD, primary disease, and the information on whether the pregnancy resulted in abortion, stillbirth, or live birth, whether the HD duration was prolonged after diagnosing the pregnancy and whether it accompanied preeclampsia were recorded. RESULTS: In this study, we reached 9038 HD female patients' data in the study. A total of 235 pregnancies were detected in 145 patients. The mean age was 35.42 (35 ± 7.4) years. The mean age at first gestation was 30.8 ± 6.5 years. The average birth week was 32 (28 -36) weeks. A total of 53.8% (no = 78) of the patients had live birth, 51.7% (no = 70) had at least one abortion in the first 20 weeks, and 13.1% (no = 19) had at least one stillbirth after 20 weeks. The rate of patients' increased numbers of dialysis sessions during pregnancy was 71.7%. The abortion rate was 22.4% in those with increased HD sessions, whereas 79.3% in those not increased HD sessions (p < 0.001). Live birth frequency was 67.2% in the increased HD sessions group and 3.4% in those who did not differ in HD sessions (p < 0.001). DISCUSSION: For the first time, we reported pregnancy outcomes in HD female patients, covering all regions of Turkey. It has been observed that;increasing the number of HD sessions in dialysis patients will decrease fetal and maternal complications and increase live birth rates.
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BACKGROUND AND AIMS: Haemodialysis (HD) patients are at increased risk for adverse short-term consequences of COVID-19. In this study, we investigated the characteristics of chronic HD patients in the post-COVID-19 period and compared them with the control group. METHOD: We conducted a national multicentre observational study involving adult chronic HD patients recovering from COVID-19. The control HD group was selected from patients with similar characteristics who did not have COVID-19 in the same center. SARS-CoV-2 RT-PCR negative patients and patients in the active period of COVID-19 were not included. RESULTS: A total of 1223 patients (635 COVID-19 groups, 588 control groups) were included in the study from the data collected from 47 centres between 21 April 2021 and 11 June 2021. The patients' baseline demographics, comorbidities, medications, HD characteristics and basic laboratory tests were quite similar between the groups (Table 1). 28th-day mortality and between 28th day and 90th day mortality were higher in the COVID-19 group than in the control group [19 (3.0%) patients and 0 (0%) patients;15 (2.4%) patients and 4 (0.7%) patients, respectively]. Presence of respiratory symptoms, rehospitalization, need for home oxygen therapy, lower respiratory tract infection and A-V fistula thrombosis were significantly higher in the COVID-19 group in the first 28 days of illness and between 28 and 90 days. Mortality was significantly associated with preexisting COVID-19, age, current smoking, use of tunneled HD catheter, persistence of respiratory symptoms, rehospitalization, need for home oxygen support, presence of lower respiratory tract infection within 28 days and persistence of respiratory symptoms. CONCLUSION: In the post-COVID-19 period, mortality, rehospitalization, respiratory problems and vascular access problems are higher in maintenance HD patients who have had COVID-19 compared to control HD patients. (Table Presented).
ABSTRACT
Study Objectives: The aim of this study was to investigate the relationship between the biomarkers of serum CRP, PCT, D-dimer, ferritin, and lymphocytes, and the survival of COVID-19 patients admitted to the Intensive Care Unit (ICU). Methods: The effect of acute phase reactants on survival were retrospectively examined in 399 patients diagnosed with COVID-19 and followed up in the ICU of Afyonkarahisar Health Sciences University Medical Faculty Hospital between 20 March 2020 and 31 December 2020. Results: The 399 patients included in the study comprised 273 (68.4%) males and 126 (31.6%) females with a median age of 68 years (IQR: 15 years). Mortality developed in 225 (56.4%) patients in ICU and 174 (43.6%) were discharged. In the ROC analysis applied to CRP, PCT, D-dimer, ferritin levels, and lymphocyte count, the AUC values were determined in the range of 0.389-0.635. D-dimer was the parameter with the highest AUC value. In the survival analysis according to the cutoff values determined for CRP, PCT, D-dimer, and lymphocyte count, these four parameters were determined to have an effect on survival (p = 0.038, p = 0.001, p = 0.012, and p = 0.018, respectively). Ferritin levels were found to be similar between the groups of survivors and nonsurvivors (p = 0.492). Conclusion: High serum CRP, PCT, D-dimer levels, and low lymphocyte count were determined to be associated with poor outcomes in the 399 patients admitted to the ICU with a diagnosis of severe COVID-19 pneumonia.